Eighty patients in the i‑STAT CG4+ group were compared with 80 patients in the laboratory group. One before‑and‑after study in a US emergency department compared bedside lactate testing using i‑STAT CG4+ with laboratory testing in patients with suspected sepsis. A prospective cohort study in 446 intubated intensive care adult patients found that partial pressure of oxygen and carbon dioxide as measured by the CG4+ cartridge could be considered acceptable surrogates to laboratory measurements. Test turnaround time was 2 minutes using the i‑STAT CG4+. A before‑and‑after study found that post‑operative mortality rates in young children and babies changed from 6.2% before i‑STAT CG4+ lactate testing was introduced to 2.4% after. Two studies evaluated the i‑STAT CG4+ cartridge in non‑emergency department settings. Of the 90 samples tested, the i‑STAT lactate values of 85 samples (94%) fell within the same risk category as the Vitros value. The Vitros system was used as a reference standard. One prospective cohort study in a US medicine and pathology laboratory assessed the correlation between 5 different systems used for lactate analysis, including the i‑STAT CG4+ cartridge. Analysis showed that the lactate measurement using the i‑STAT was accurate for clinical decision‑making compared with the laboratory test. Five used the CG4+ cartridge, 1 used the CHEM8+ cartridge and the other used both CG4+ and CHEM8+ cartridges.Ī prospective cohort study in 1 US emergency department assessed the diagnostic test accuracy of lactate in serum measured using the CG4+ cartridge for predicting mortality in 669 patients with suspected sepsis. Seven studies using i‑STAT with findings relevant to the emergency department setting are included in this briefing.
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